Inoculation of mice with these cells demonstrated that on day 49 post-inoculation mice bearing cancer cells overexpressing PATZ1 or PP4R2 (A549pPATZ1-GL or A549pPP4R2-GL) developed the least whereas, those bearing cancer cells with downregulation of PP4R2 (A549shPP4R2-1-GL or A549shPP4R2-2-GL) developed the most tumor nodules (Figure 7A and 7B). This evidence concerns the gene PPP4R2 and neoplasm.