Our results suggest that the presence of PATZ1 and PP4R2 negative feedback loop on IKK/NF-κB signaling as depicted in Figure 8 may prevent cancer cells from over-stimulation from growth factors or inflammatory mediators so that they can postpone early dissemination and accumulate to form visible or even massive size of primary tumors to decrease the chance of being individually destroyed by immune cells. This evidence concerns the gene NFKB1 and cancer.