PPP4R2 and cancer: Downregulation of PP4R2 in cancer cells overexpressing PATZ1 (A549pPATZ1/shPP4R2-1-GL and A549pPATZ1/shPP4R2-2-GL) resulted in the development of about the same number of tumor nodules as mice bearing A549GL, A549EV-GL or A549shCont-GL cells (Figure 7A and 7B).