An increase of the association of PATZ1 protein with the PP4R2 gene at about +363 of transcription start site region was observed in PIP3-treated A549 and CL1-5 lung cancer cells (Supplementary Figure S4C), indicating that PIP3 induces PATZ1 that directly binds to the promoter region of PP4R2 gene and turns on PP4R2 transcription. The gene discussed is PATZ1; the disease is lung cancer.