NOTCH1 and lung adenocarcinoma: In addition, NOTCH1 expression significantly correlated with a non-smoking habit of patients (χ2=7.325, P=0.026), where 12 of 24 non-smokers patients derived tumors showed upregulation of NOTCH1 transcript, consistent with previously described NOTCH1 upregulation in non-smokers in other diseases including lung adenocarcinoma [31-33].