Consistent with amplification and over expression of Notch pathway components, Immunohistochemical analysis for activated NOTCH1 intracellular domain (NICD) in a set of 50 patients indicated strong immunoreactivity for active Notch signaling present in 40% tumor samples (Figure 1D-1E, Supplementary Figure S3A–S3C). Here, NOTCH1 is linked to neoplasm.