The results revealed that knockdown of SPRY4-IT1 could obviously induce cell apoptosis, the proportion of apoptotic cells following SPRY4-IT1 siRNA treatment was increased in LoVo and SW480 cells (Figure 4A and 4B), suggesting that SPRY4-IT1-mediated promotion of CRC cell proliferation seems to be mediated by regulation of apoptosis. This evidence concerns the gene HAUS3 and colorectal carcinoma.