Insulin regimens did not affect blindness (RR: 1.10, 95 % CI: 0.76 to 1.60) (Fig. 14), or renal failure or doubling of serum creatinine level (RR: 0.68, 95 % CI, 0.43 to 1.06) (Fig. 15), compared to placebo or diet alone. The gene discussed is INS; the disease is blindness (disorder).