The next most present loss was 17p13, which incorporates just five genes enriched by GO pathway analysis: P2RX5 and P2RX1, encoding ligand gated Na+/Ca2+ ion channels regulated by purinergic signaling, TRPV1, a non-selective ion channel, ITGAE, an integrin involved in E-cadherin ligation, and C1QBP, a poly-phenotypic protein that is commonly associated with tumor progression [33] but also involved in increased glycolysis and the Warburg effect [34]. The gene discussed is ITGAE; the disease is neoplasm.