The SFRP1 rs7832767 CT/TT genotypes were shown to significantly increase MI risk in subjects of age≤67 and under (AOR = 2.31, 95% CI = 1.43-3.74), men (AOR = 1.98, 95% CI = 1.21-3.24), smokers (AOR = 3.05, 95% CI = 1.59-5.84), drinkers (AOR = 9.75, 95%CI = 2.64-36.10), subgroup with hypertension (AOR = 5.99, 95% = 3.10-11.56), subgroup with diabetes (AOR = 4.77, 95% CI = 3.09-7.35) and without diabetes (AOR = 0.32, 95% = 0.14-0.73), subgroup with dyslipidemia (AOR = 1.59, 95% CI = 1.04-2.41) as well as obesity (AOR = 1.50, 95% CI = 1.07-2.10). The gene discussed is SFRP1; the disease is obesity due to melanocortin 4 receptor deficiency.