We performed stratification analyses in terms of age, sex, smoking and drinking status, hypertension, diabetic diseases, dyslipidemia, and obesity to evaluate how these variables modified the association between the SNPs (SFRP1 rs7832767 C > T, CTNNB rs2293303 C > T and WISP1 rs16893344 C > T) and MI risk (Table 3). This evidence concerns the gene CCN4 and hypertensive disorder.