To precisely determine the association of the Wnt pathway gene polymorphisms with MI risk, we investigated the genotype distributions of several single nucleotide polymorphisms (SNPs) in key genes within this important pathway (i.e., rs7832767 C > T in SFRP1 gene, rs2293303 C > T in CTNNB1 gene, rs16893344 C > T in WISP1 gene) in the case-control study with 465 MI cases and 485 controls. This evidence concerns the gene CTNNB1 and myocardial infarction.