To investigate the role of SOX10, MITF, and FOXD3 and the reported effects due to BRAF status in ERBB3 regulation, we depleted the three former genes individually and in combination for MITF/FOXD3 by the use of siRNA in three melanoma cell lines: WM983B, MeWo and WM115. The gene discussed is BRAF; the disease is melanoma.