To further explore a link between HBxΔ31 expression and Maspin, RhoGDIα and CAPZB repressions in the same clinical specimens, we examined the mRNA levels of Maspin, RhoGDIα and CAPZB in 40 specific HCC specimens with HBxΔ31-positive by real-time PCR. This evidence concerns the gene CAPZB and hepatocellular carcinoma.