To determine the clinical significance of Maspin, RhoGDIα and CAPZB down-regulation by HBxΔ31, we first examined the expression levels of Maspin, RhoGDIα and CAPZB in a cohort of 102 HBV-related HCC and their matching non-tumorous tissues using immunohistochemistry assay. The gene discussed is SERPINB5; the disease is hepatocellular carcinoma.