Intriguingly, some of HBxΔ31-repressed proteins, for example Maspin and RhoGDIα are reported to have anti-metastatic functions [23, 24], indicating a potential molecular mechanism that HBxΔ31 promotes HCC progression by reducing the expression of a subset of metastasis suppressors. The gene discussed is SERPINB5; the disease is hepatocellular carcinoma.