RUNX2 and acute myeloid leukemia: To further evaluate the combinatorial approaches in AML under the conditions mimicking the hypoxic bone marrow microenvironment, we treated OCI-AML3 and U937 cells and three primary AML samples at the fixed concentration of each agent in co-culture with mesenchymal stromal cells (MSC), under hypoxia (1% oxygen) or normoxia (21% oxygen) (Figure 8; Supplementary Figure S7).