The anti-leukemic efficacy of MLN0128 was examined in four AML cell lines: FLT3-ITD-mutated MOLM13 and MV4-11 cells; NPM1 and N-Ras-mutated OCI-AML3 cells; and in PTEN-null U937 cells. The gene discussed is FLT3; the disease is acute myeloid leukemia.