Even though the beneficial effects of DPP-4 inhibition on the cardiovascular system have been explored in both animal models and in type 2 diabetic patients [11], to the best of our knowledge, the potential role of these compounds to target vascular stiffness in a female rodent model of insulin resistance due to over-nutrition without frank hyperglycemia or blood pressure elevation has not been studied. This evidence concerns the gene DPP4 and Insulin resistance.