Acute promyelocytic leukemia (APL) was a specific type of acute myeloid leukemia (AML) associated with the fusion of promyelocytic (PML) gene with the retinoic acid receptorα(RARA) gene (PML-RARA) generated by the t(15;17) translocation [1–3]. This evidence concerns the gene RARA and acute promyelocytic leukemia.