In the same line of evidence, others have demonstrated that the constitutive activation of PI-3K/Akt is associated with the resistance of certain cell types such as rheumatoid arthritis synovial-like synoviocytes to death signals including Fas ligand, TNF and TNF-related apoptosis-inducing ligand (TRAIL) [52]. This evidence concerns the gene FASLG and rheumatoid arthritis.