INS and type 2 diabetes mellitus: In the case of the endocrine pancreas-restricted secretory granule zinc transporter SLC30A8/ZnT8, identified in GWA studies for T2D [6], this approach has been pivotal in highlighting the role of the transporter in the control of secretory granule formation and Zn2+ storage [7, 8] insulin secretion [9] and hepatic clearance of the hormone [10].