In rodents, early-life exposure to GCs causes intrauterine growth retardation followed by a period of post-natal catch-up growth and is associated in adults with tissue-specific alterations to Gr mRNA expression, including t is associated in adults with tissue-specific alterations he liver, leading to hepatic expression of the gluconeogenic enzyme pepck and hyperglycaemia. The gene discussed is NR3C1; the disease is Hyperglycemia.