AGTR1 and Hypertension: In contrast, AT1R blockade or deletion of the AT1R gene normalizes the hypertension in GRK4γ142V transgenic mice.77 Our recent study also showed that, due to higher nuclear factor κB activity with more nuclear factor κB bound to the AT1R promoter, both AT1R expression and AT1R‐mediated vasoconstriction are higher in the aorta of GRK4γ142V than GRK4γ wild‐type transgenic mice.21 In GRK4γ142V transgenic mice.