A number of studies have shown that GRKs are associated with hypertension, blood pressure response to antihypertensive medicines, and adverse cardiovascular outcomes of antihypertensive treatment.8, 9, 10, 11 In this paper, we reviewed our evolving understanding of the role of GRKs in hypertension, summarized the current knowledge of GRK‐mediated regulatory mechanisms, and highlighted the potential for targeting GRKs in the treatment of hypertension. The gene discussed is GZMK; the disease is hypertensive disorder.