GRK6 and Hypertension: Renal GRK6 levels are lower in hypertensive participants and SHRs than their normotensive controls111; however, GRK6 expression is increased in spontaneously hypertensive heart failure rats.66 Moreover, subcellular redistribution of GRK6 in spontaneously hypertensive heart failure rats is also involved in abnormal remodeling of cardiac myocytes in hypertensive hypertrophy and failure.66 GRK6 is also important in the negative regulation of inflammation,112 which is intimately involved in the regulation of blood pressure and development of hypertension.