GRK4 and hypertensive disorder: The human GRK4 gene locus (4p16.3) is embedded in a gene cluster region on chromosome 4p16 that includes genes encoding dopamine receptor type 5 (4.p16.1) and α‐adducin (4p16.3), 2 variants of which (ADD1 and GRK4) are linked to hypertension.16, 69, 70 The human GRK4 gene is composed of 16 exons extending over 75 kb of DNA.