The human GRK4 gene locus (4p16.3) is embedded in a gene cluster region on chromosome 4p16 that includes genes encoding dopamine receptor type 5 (4.p16.1) and α‐adducin (4p16.3), 2 variants of which (ADD1 and GRK4) are linked to hypertension.16, 69, 70 The human GRK4 gene is composed of 16 exons extending over 75 kb of DNA. This evidence concerns the gene GRK4 and Hypertension.