Accordingly, molecular chaperones of the heat shock protein-90 (Hsp90) family, including Hsp90 [7] and its homolog, TNFR-associated molecule-1 (TRAP-1) [8], become overexpressed in mitochondria of tumor cells compared to normal tissues [9] and preserve the folding and activity of key effectors of organelle homeostasis [10]. Here, TRAP1 is linked to neoplasm.