SDHB and neoplasm: As most epithelial tumors rewire their metabolism toward glycolysis [32], a role of mitochondrial bioenergetics in cancer has been controversial, and SDHB itself has been at times dubbed as a “tumor suppressor.” On the other hand, oxidative phosphorylation remains an important energy source in most cancers [33], fueling critical disease traits such as tumor repopulation after oncogene ablation [34] and drug resistance [35].