Mir133a has been implicated in modulation of the VSMC phenotype in general and specifically in the regulation of VSMC proliferation in mouse aorta.23,30 However, as miR133a was unchanged in other hypertensive vessels that displayed reduced Kv7.4 expression and miR153 was consistently up-regulated in these vessels, we focused on defining the impact of miR153 on Kv7.4 in hypertension. Here, KCNQ4 is linked to hypertensive disorder.