KCNQ1 and hypertensive disorder: Moreover, KCNQ1 and KCNQ5 are down-regulated by other miRs, namely, miR1/133 and miR190, respectively.41,42 Nevertheless, the parallel change in miR153 and Kv7.4 is clear raising the possibility that correction of the miR153 up-regulation that leads to the aberrant Kv7 channel function/expression, vasoconstriction, and vascular wall thickening, through the use of miR sponges,43 chemical inhibitors,44 and antagomirs45 as a potential treatment for hypertension.