Sex and preoperative alpha-fetoprotein correlated significantly (p < 0.05) with MFN2 mRNA expression, whereas age, HBsAg, HBV-DNA replication, liver cirrhosis, tumor number, tumor size, vascular invasion, lymph node metastasis, intrahepatic metastasis, liver capsular invasion, differentiation, and TNM stage did not. This evidence concerns the gene AFP and cirrhosis of liver.