Reproductive disorders such as Kallmann Syndrome [2], Idiopathic Hypogonadotropic Hypogonadism [3], Prader-Willi Syndrome [4], and CHARGE Syndrome [5], are attributed to disruptions in Gnrh1 gene expression, GnRH neuron signaling, and/or neuronal maturation. Here, GNRH1 is linked to CHARGE syndrome.