In a multivariate analysis adjusted for the clinical model, [TIMP-2]•[IGFBP7] of more than 0.3 was associated with death or RRT only in subjects who developed AKI (compared with levels of not more than 0.3: HR 1.44, 95 % CI 1.00–2.06 for levels of more than 0.3 to 2.0, P = 0.05; and HR 2.16, 95 % CI 1.32–3.53 for levels of more than 2.0, P = 0.002) [19]. This evidence concerns the gene IGFBP7 and acute kidney injury.