TGFB1 and juvenile idiopathic arthritis: The TREAT expression data suggest a previously unrecognized role for transforming growth factor (TGF)B1 in JIA, although its role in adult rheumatoid disease has been long recognized [23], and we have shown that TGFB1 is overexpressed in children with active JIA on therapy compared with children who have achieved clinical remission on medication [24].