Of 9 colonic polyps analysed, the Htra1 promoter was unmethylated in 4 polyps (polyps 13, 22, 145 and 147), methylated in 4 polyps (polyps 18, 98, 99 and 101) and partially methylated in one polyp (polyp 97). This evidence concerns the gene HTRA1 and intestinal disorder.