However, while some, notably associations between COMT Val158Met and dopamine-dependent cognitive function (Egan et al, 2001; Farrell et al, 2012) and anxiety-related phenotypes (Olsson et al, 2005; Pooley et al, 2007), show promise, non-replications exist; thus, associations between COMT and neuropsychiatric phenotypes remain controversial (Farrell et al, 2015). Here, COMT is linked to Anxiety.