Measurement of CA125 in serum are the preferential marker for epithelial ovarian cancer, with CA125 levels higher than 35 U/mL being considered abnormal and associated with 90 % of ovarian carcinoma; levels of CA125 are useful to evaluate the response to chemotherapy, relapse and progression of the disease [5] and measurement of CA125 levels in the screening of ovarian cancer in general population has been largely evaluated [6, 7]. This evidence concerns the gene MUC16 and ovarian carcinoma.