TNF and malignant colon neoplasm: It is noteworthy that while our studies were in progress, an independent group documented that PRDX1 depletion in the colon cancer cell line SW480 enhanced the production of ROS, and increased the expression levels of pro-inflammatory cytokines such as the tumor necrosis factor-α and interleukin (IL)-1β, as well as the chemokines IL-8 and CXCL1, and that this induction occurs by partial activation of NF-κB57.