ACTA1 and myopathy: Particularly a predominant anterior lower leg involvement is always presents in NEB-myopathies and in ACTA1-myopathies with tibialis anterior involved first [35], but the different histological framework at muscle biopsy and the prevalent involvement at thigh level of posterior compartment in ACTA1 and NEB mutations, comparing with the prevalent involvement of vasti muscles in myosinopathies could direct genetic tests.