MYH7 and heart disorder: As expected both cardiac and skeletal muscle disorders can arise from a defect of MYH7. MYH7- related cardiac diseases are more frequent and include familial hypertrophic/dilated cardiomyopathy (MIM 192600), and left ventricular non-compaction (LVNC) cardiomyopathy (MIM 613426) with more than 200 mutations described so far [2].