In summary, using a genome-wide approach of screening for gene-gene interactions, we identified and found suggestive evidence of replication for an interaction in asthma (rs910652 × rs11684871), where one of the participating SNPs (rs910652) is in close proximity to ADAM33 and the other (rs11684871) is located in or near GLI2. Both SNPs are highly plausible asthma risk variants, given known associations between ADAM33 and asthma, a previously reported association between rs910652 and lung function, and the roles of GLI2 in T-cell regulation and lung development. This evidence concerns the gene ADAM33 and asthma.