Similarly, increasing tumour stage was associated with decreased TTR and CSS (TTR: log-rank test, p = 0.005; Cox test, p = 0.001, HR 1.52, 95 % CI: 1.18–1.96 and CSS: log-rank test, p < 0.0001; Cox test p < 0.0001, HR 1.94, 95 % CI: 1.53–2.45). This evidence concerns the gene TTR and neoplasm.