KLK3 and prostate cancer: Our finding that the combination of low MT/C ratios and PAS levels in excess of 10 ng/ml conferred the highest tendency that a person may have prostate cancer and advanced-stage disease prostate cancer suggests that we might consider the biomarker of MT/C ratio in urine to be an additional tool for judging whether the prostate biopsy is needed or not, when PSA levels are elevated.