FLT3 and acute myeloid leukemia: In addition, we found that the Pbx1 and Evi-1 expression levels were significantly reduced in the FLT3-ITD+ AML cells (N = 78) compared to FLT3-ITD- AML cells (N = 190, P < 0.05, Fig 8D, middle and lower panels), which are listed in the GSE1159 dataset (www.ncbi.nlm.nih.gov/geo/) [42].