Therefore, the FGF21-resistance in baroreflex afferent pathway might also be an important aspect to understand the pathogenesis of the metabolic disorder related hypertension, and it is attractive to investigate the role of FGF21 on hypertension by receptors (klb-FGFRs) knockdown/knockout in the NTS or NG in further investigation. This evidence concerns the gene FGF21 and metabolic disease.