The “HCC-specific” signature included the following genes: ABL2, ACSL4, AKR1B10, ATP6V1C1, BUB3, CASK, CCT3, CDKN2A, EIF3H, ENAH, FAM122B, FLVCR1, GBAP1, GPC3, HKDC1, HNRNPU, ICK, IGF2BP3, IRS1, LARS, LOC344887, LOC389834, MIB1, MRPL9, MTR, OTUD6B, PHF20L1, PRCC, PRKDC, PSMD4, PSPH, RAD21, RBM12B, ROBO1, RRM2B, SMARCC1, SMYD2, SMYD3, SRXN1, TCERG1, TERF1, TMEM106C, TMEM68, TSHZ2, TTC13, UBE2Q1, UBR5, UTP14A, VASH2, ZKSCAN3, ZNF260, ZNF623 (Fig. 3A). This evidence concerns the gene IRS1 and hepatocellular carcinoma.