In particular, according to HCC modulated genes, a specific activation of several factors was deduced, including E2F1, ERBB2, CCND1, RABL6, HGF, MYC, VEGF, IRF1, TNF, STAT1, JUN, TRAF2, AKT, WNT1 and CTNNB1. Here, TNF is linked to hepatocellular carcinoma.