Furthermore, the analysis identified several tumor suppressor genes (i.e., CDKN2A, RB1, let-7, RB, KDM5B, BNIP3L, RBL2, NUPR1, STK11) with negative activation z-score, predictive of an inhibited state associated with HCC. The gene discussed is RBL2; the disease is hepatocellular carcinoma.