In particular, according to HCC modulated genes, a specific activation of several factors was deduced, including E2F1, ERBB2, CCND1, RABL6, HGF, MYC, VEGF, IRF1, TNF, STAT1, JUN, TRAF2, AKT, WNT1 and CTNNB1. This evidence concerns the gene E2F1 and hepatocellular carcinoma.