Of note, the SSc-OS patients often had non-SSc-specific autoantibodies (68.0%; P < 0.0001) such as those directed against U1RNP, PM/Scl, SSA/Ro (Sjögren's syndrome A/Ro60 antigen), SSB/La (Sjögren's syndrome antigen B/La antigen), and Jo-1 (histidyl tRNA synthetase). This evidence concerns the gene TRIM21 and systemic sclerosis.