Recently, further relationships of VWF and OPG were given by Rutten et al., who measured the “active VWF” fraction and highlighted that in 1026 first ST-segment elevation myocardial infarction (STEMI) cases the plasma medians of total VWF, “active VWF”, OPG and the ratio of VWF to “a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13” (ADAMTS-13) were at a significantly high risk for STEMI. This evidence concerns the gene TNFRSF11B and ST Elevation Myocardial Infarction.