NAF1 and melanoma: These studies have shown that the same cluster of LTL-associated alleles (OBFC1, ZNF208, TERC, TERT, RTEL1, ACTP2, and NAF1) is a risk indicator for melanoma [4], lung cancer [57], and coronary heart disease [7], such that when the joint effect of the alleles results in a comparatively long LTL, the risk for melanoma and lung cancer is increased, whereas the risk for coronary heart disease is diminished.