In a previous experience, we reported that MetS was even more prevalent (44 %) in patients at risk of PCa for an elevated PSA or an abnormal digital rectal examination and we also showed that MetS was associated with an increased risk (OR: 3.8; 95 % CI 1.33-10.9) of Gleason score ≥ 7 in patients with PCa at biopsy [1]. The gene discussed is KLK3; the disease is posterior cortical atrophy.