Interestingly, one of the lead candidate variants, rs17293632, located within an intergenic region of the SMAD3 gene was linked to a new association for CAD, rs56062135 (r2=1.0; D′=1.0; Europeans) at 15q22.33, (additive model P=5.72E−09)5 (Fig. 4a), while also being previously associated with chronic inflammatory bowel disease39 and Crohn's disease40 (Fig. 4a,b). Here, SMAD3 is linked to coronary artery disorder.