Granulosa cells from women with PCOS had significantly reduced expression of fractalkine compared with those from Ctl individuals (0.642 ± 0.070 versus 1.610 ± 0.551, respectively; P < 0.05; n = 10 and n = 6, respectively; Fig. 1B). This evidence concerns the gene CX3CL1 and polycystic ovary syndrome.