In a mouse model of Marfan syndrome, many of the phenotypic effects have been attributed to function of fibrillin-1 in regulating the bioavailability of transforming growth factor β (TGFβ) family members [68], [69], (including activins and bone morphogenic proteins) which inhibit adipogenesis [70], [71]. The gene discussed is TGFB1; the disease is Marfan syndrome.