A genotype-phenotype correlation exists between the lipodystrophy phenotype and frameshift mutations at the 3′ end of the FBN1 gene, in the second last exon, coding Exon 64 (exon numbering from http://www.umd.be/FBN1/; shown as Exon 65 in the Ensembl Genome Browser) [9], [10], [11], [12], [13], [14]. The gene discussed is FBN1; the disease is lipodystrophy.