More than 20% of APS cases present as a stroke.54 The revised classification criteria for APS (2006) require both clinical (i.e., ischemic stroke) and laboratory criteria for diagnosis (i.e., a positive anti–β2-glycoprotein I [anti-β2GP1] or anticardiolipin antibodies [ACL] or lupus anticoagulant [LA] detected in the blood and persisting for >12 weeks).55 The gene discussed is APOH; the disease is ischemic stroke.