ACLY and Stroke: Anti-β2GP1 and LA are strongly associated with stroke.56 However, the evidence for ACL as a predictor of APS and stroke is conflicting.56,57 Furthermore, HIV is associated with ACL and LA but not anti-β2GP1.52 As anti-β2GP1 is specific for stroke in HIV populations, the consensus was to refine the laboratory definition to include the detection of anti-β2GP1 in combination with ACL or LA.