To investigate whether there was an association between MTHFR C677T, SELE L554F, FGB-455G>A, GNB3 C825T, ZNF259 C>G, PSRC1 A>G, CETP I405V, LPL S447X and LPA C>T polymorphisms and MetS, we carried out genotyping using genomic DNA extracted from peripheral blood samples. This evidence concerns the gene GNB3 and metabolic syndrome.