In the present study, we investigated the association of nine polymorphisms involved in lipid metabolism and hypertension, including MTHFR rs1801133, SELE rs5355, FGB rs1800790, GNB3 rs5443, PSRC1 rs599839, LPL rs328, Lp(a) rs3798220, ZNF259 rs964184 and CETP rs5882 in. The gene discussed is MTHFR; the disease is hypertensive disorder.