This is the first study evaluating the association of MTHFR- rs1801133, SELE-rs5355, FGB-rs1800790, GNB3- rs5443, PSRC1- rs599839, LPL- rs328, Lp(a)- rs3798220, ZNF259-rs964184 and CETP-rs5882 polymorphisms and MetS in Iranian patients. This evidence concerns the gene MTHFR and metabolic syndrome.