Some groups have reported an increase in the transcriptional levels of EZH2 (a H3K27 histone methyl-transferase) in the luminal breast cancer subtype (Healey et al. 2014), and an association between increased EZH2 activity and poor prognosis has been reported (Jene-Sanz et al. 2013; Holm et al. 2012). Here, EZH2 is linked to breast carcinoma.