A variety of limb malformations including synpolydactyly and hand-foot-genital syndrome are known to be caused by specific mutations in HOXD13 and HOXA13, respectively (Muragaki et al. 1996; Mortlock and Innis 1997) In 2003, Wang identified 12 alleles at Hox4Ep-a microsatellite marker on HoxD gene; transmission of disequilibrium was found at the 12th allele, indicating that HoxD may be a potential gene for ICTEV (Wang et al. 2003). This evidence concerns the gene HOXA13 and hand-foot-genital syndrome.