ALK and adenocarcinoma in situ: The ALK rearrangements frequencies were: 14.8 % (16/108) for variants of invasive adenocarcinoma (15 invasive mucinous adenocarcinoma and 1 colloid adenocarcinoma), 10.3 % (20/195) for solid predominant, 7.6 % (13/170) for micropapillary predominant, 2.8 % (29/1035) for acinar predominant, 2.5 % (3/119) for minimally invasive adenocarcinoma, 2.0 % (11/539) for papillary predominant, 0.9 % (1/114) for lepidic predominant, and 0 % (0/19) for adenocarcinoma in situ, respectively.