GPR17 and neoplasm: Finally, treatment of human glioblastoma multiforme cells with UDP, UDP-glucose or LTD4, that act as agonists at the new P2Y-like GPR17 receptor, reduced the formation of glioma spheres, suggesting that GPR17 stimulation on highly proliferating tumor OPCs may drive their differentiation to the oligodendroglial fate, negatively affecting both tumor proliferation and self-renewal (Dougherty et al., Cancer Res 72:4856, 2012).