IL22 and Crohn ileitis: Namely, in the colon, IL-22 exerts its anti-inflammatory properties [19], whereas in the small intestines, however, IL-22 acts as an pro-inflammatory mediator, given that in acute murine ileitis following peroral high dose Toxoplasma gondii infection, immunopathology was characterized by an IL-23p19 dependent IL-22 up-regulation leading to small intestinal necrosis [20, 21].