The induction of insulin like growth factor activity, prostanoid ligand receptors (which can activate PPARs), translational machinery, cytoskeletal remodeling (pathogenic E. coli infection), insulin signaling, interconnected cell membrane structures, and transcriptional regulation were the most dominant pathways at 48 hours versus control (40 networks of 101 are shown in Fig. 5, 48 vs 0). The gene discussed is INS; the disease is escherichia coli infection.