In fact, FOXM1 is overexpressed in various human malignancies, including prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver and kidney cancer [52, 53], and its oncogenic activity is downstream of Ras [54] and cyclin D1 [38], which are often implicated in epithelial tumors. This evidence concerns the gene CCND1 and kidney cancer.