TSLIG1 and Anxiety: We found that the PV;Arch-GFP(+/-) mice with 594nm laser stimulation (laser on) spent increased time in the open arm of the EPM, when compared with the PV;Arch-GFP(+/-) mice without laser stimulation (laser off) or the laser-stimulated PV;Arch-GFP(-/-) group (Figure 2C), indicating that inhibiting the activity of CeA PV+ interneurons could attenuate morphine withdrawal–increased anxiety levels.