PTEN, a regulator of PI3-K and Akt signalling previously reported to be involved in stromal-tumour interactions and senescence [26, 27], is a putative protein-coding target of miR-335, and of a number of other miRNAs identified as up-regulated in senescent cells displaying a robust SASP (Fig 4A, Table S3). Here, PTEN is linked to neoplasm.